Oral Biology Teaching Responsibilities: Histology, Oral Histology & Embryology Research Interests: Extracellular Matrix Proteins, G-Proteins Service Activity: Research Committee Past Honors & Accomplishments: NIH Postdoctoral Fellowship, Blanche Widamen Fellowship, Bukey Fellowship Selected Publications & Abstracts: Barritt, L.C., and J.B. Turpen. Characterization of Lineage Restricted Forms of a Xenopus CD45 Homologe. Dev. and Comp. Immunology 19 (1995): 525-536. Barritt, L.C., and K.W. Beisel. G-Protein Expression in Rat Inner Ear Hair Cells. Molecular Biology of Hearing and Deafness. S144A (1995) 144. Beisel, K.W., L.C. Barritt, B.J. Kelly, J. Pinnet, p. Ing, K.B. Avraham, N.J. Copeland, and N.A. Jenkins. Cloning, Characterization and Chromosomal Location of a Novel Voltage-Gated Potassium Channel Gene, KCNG1. Molecular Biology of Hearing and Deafness. S88A (1995) 88. Beisel, K.W., B.J. Kelly, N.C. Lofton, and L.C. Barritt. Expression of Voltage-Gated Potassium Beta Chain Genes in the Inner Ear of the Rat. Molecular Biology of Hearing and Deafness. S130A (1995) 130. D. Roselyn Cerutis, Ph.D., Assistant Professor Teaching Responsibilities:Biochemistry, Physiology Research Interests: Our laboratory is interested in lysophosphatidic acid (LPA) as a mediator in oral wound healing. LPA is a potent, simple phospholipid mediator released from activated platelets together with platelet-derived growth factor, transforming growth factor (TGF)-α and –β, and other platelet peptides. LPA has hormone and growth factor-like properties. It binds to and activates its cognate G protein-coupled receptors (LPA1-3), each of which can signal through Gi, G12/13(LPA1-2) and Gq . Using an in vitro oral wound healing model, we have provided the first evidence that LPA controls the regenerative responses of human gingival and periodontal ligament fibroblasts. The present focus of our research is to understand the biochemical and molecular regulation of the LPA receptors on these cells, and to define the contribution played by each receptor subtype in controlling these “healing” responses. We employ a combination of cellular, biochemical, and molecular approaches to investigate the specific signaling pathways associated with the actions of these receptors. Other interests: Adrenergic and serotonergic receptor pharmacology.
Service Activity: Strategic Planning Committee Past Honors & Accomplishments: Post-Doctoral Fellowship, NRSA Training Grant Selected Publications & Abstracts: Ebadi, M., R.M. Bashir, M.L. Heidrick, F.M. Hamada, H.E. Refaey, A. Hamed, G. Helal, M.D. Baxi, D.R. Cerutis, and N.K. Lassi. Neurotrophins and their receptors in nerve injury and repair. Neurochem. Int. 30 (1997): 347-74. Cerutis, D.R., M. Nogami, J.L. Anderson, J.D. Churchill, D.J. Romberger, S.I. Rennard, and M.L. Toews. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am. J. Physiol. 273 (1997): L10-5.Rojas, P., D.R., Cerutis, H.K. Happe, L.C. Murrin, R. Hao, R.F. Pfeiffer, and M. Ebadi. 6-Hydroxydopamine-mediated induction of rat brain metallothionein I mRNA. Neurotoxicology 17 (1996): 323-34. Zhu, S.J. D.R. Cerutis, J.L. Anderson, and M.L. Toews. Regulation of hamster alpha 1B-adrenoceptors expressed in Chinese hamster ovary cells. Eur. J. Pharmacol. 299 (1996): 205-12. Cerutis DR, Dreyer A, Cordini F, McVaney TP, Mattson JS, Parrish LC, Romito L, Huebner GR, and Jabro M. Lysophosphatidic acid modulates the regenerative responses of human gingival fibroblasts and enhances the actions of platelet-derived growth factor. J Periodontol 2004:75:297-305. Cerutis DR, Nogami M, Anderson JL, Romberger DJ, Rennard SI, and Toews ML. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am J Physiol 1997;273:L10-L15.
Teaching Responsibilities: General Gross Anatomy, Head & Neck Anatomy Research Interests: Anatomy & Dysfunction of the TMJ Service Activity: Curriculum, Academic Misconduct, Faculty Council Vice President Past Honors & Accomplishments: Omicron Kappa Upsilon Selected Publications & Abstracts: Jergenson, M.A. and J.M. Barton. The Occurrence of TMJ Disc Perforations in an Aging Population. Journal of Dental Research, 77 (1998): 77. Jergenson, M.A. and J.M. Barton. The Path of the Lingual Nerve into the Oral Cavity. Journal of Dental Research, 76 (1997): 20. Jergenson, M.A. and J.M. Barton. Gross Dissection of the Insertion of the Lateral Pterygoid Muscle. Journal of Dental Research, 75 (1996): 20. Teaching Responsibilities: General Gross Anatomy, Head & Neck Anatomy, General Neuroscience Research Interests: Chronic & Fulminant Hepatic Encephalopathy, Role of Metallothionein in Neurodegeneration, Parkinson’s Disease Service Activity: Admissions Committee, Research Committee, Biomedical Education Committee Past Honors & Accomplishments:Outstanding Instructor of the Year 1996-97, Outstanding Instructor of the Year 1997-98, Health Futures Foundation Development Award 1997, Health Futures Foundation Development Award 1998 Selected Publications & Abstracts: Norton, N.S., J.R. McConnell, and J.F. Rodriguez-Sierra. Behavioural and Physiological Sex Differences Observed in an Animal Model of Fulminant Hepatic Encephalopathy (FHE) in the Rat. Physiol. and Behav., 62 (1997): 1113-1124. Ebadi, M., J.F. Rodriguez-Sierra, and N.S. Norton. Glutathione and Metallothionein in Neurodegeneration - Neuroprotection of Parkinson’s Disease. Neuroendocrinology Letters, 18 (1997): 111-121. Thompson, M.C., N.S. Norton, J.F. Rodriguez-Sierra, and L. Lippiello. Growth Hormone-Releasing Hormone Depletion in the Female Rat: Similarities to Aging. J. Gerontol. A. Biol. Sci. Med. Sci., 51 (1996): B83-90 Norton, N.S., J.R. McConnell, R.K. Zetterman, and J.F. Rodriguez-Sierra. A Quantitative Evaluation of Magnetic Resonance Image Signal Changes of the Brain in Chronic Hepatic Encephalopathy. J. Hepatol. 21 (1994): 764-770.
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